Fer (fps/fes related) Tyrosine Kinase (FER, Phosphoprotein NCP94, TYK3)

Cat no: F3965-05A

Supplier: United States Biological

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Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells (1). FER is found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction. Its ubiquitous expression and its subcellular location indicate that it may be involved in key regulatory processes (2). The group IV cytoplasmic protein-tyrosine kinase Fer has been linked to cellular signaling responses to many different stimuli, including growth factors and cytokines. Data suggest a biological role for Fer in regulation of leukocyte recruitment during the innate immune response (3). Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:5,000 Flow Cytometry: 1:50 Immunoprecipitation: 1:30 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

Catalogue number:	F3965-05A
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Flow Cytometry, Immunoprecipitation, Western Blot
Size:	100ul
Form:	Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type:	Mab
Isotype:	IgG
Purity:	Supernatant
References:	1. Wissing J, et al. Mol Cell Proteomics 6(3):537-47, 2007. 2. Hao QL, et al. Mol cell Biol. 11(2):1180-3, 1991. 3. McCafferty DM, et al. J Immunol 168(10a):4930-5, 2002.
Additional info:	Recognizes human Fer.

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Fer (fps/fes related) Tyrosine Kinase (FER, Phosphoprotein NCP94, TYK3)

Cat no: F3965-05A

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