FEZ2, CT (Fasciculation and elongation protein zeta 2, HUM3CL, MGC117372, Pre-T/NK cell-associated protein 3Cl, Zygin-2, Zygin II)

Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C. elegans UNC-76 (1,2). In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues. FEZ2 interacts with protein kinase C (PKC)-Z substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-Z, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC-Z in a tissue non-specific manner (1). FEZ2 can interact with FEZ1 through its c- terminal regions and especially its coiled-coil region (5). At least two isoforms of FEZ2 are known to exist. \n\nApplications: \nSuitable for use in Western Blot Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5

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SPECIFICATIONS

Catalog Number

F3965-07A

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Can

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Fujita T, Ikuta J, Okajima T, et al. Identification of a tissue- non-specific homologue of axonal fasciculation and elongation protein zeta-1. Biochem. Biophys. Res. Commun. 2004; 313:738-44. 2. Kuroda S, Nakagawa N, Tokunaga C, et al. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C Z-interacting protein. J. Cell Biol. 1999; 144:403-11. 5. Assmann EM, Alborghetti MR, Camargo MER, et al. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. J. Biol. Chem. 2006; 281:9869-81.

Additional Info

Recognizes human FEZ2. Species crossreactivity: Mouse and rat.