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Fibrillin (FITC)

Cat no: F4194-05A

Fibrillin (FITC)

The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear.1 In immunohistochemical staining of paraformaldehyde-fixed human skin, mAb labels the elastic framework and more specifically the oxytalantic network close to the epidermis. The antibody also exhibits discrete staining of normal fibroblasts in culture and of extracellular (elastin) fibrils in a variety of tissues.2,3 There is an aberrant expression of fibrillin in Marfan syndrome.4\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

F4194-05A

Size

200ug

Applications

IF, IHC, WB

Hosts

Mouse

Reactivities

Bov

Form

Supplied as a liquid in PBS, 0.1% sodium azide. Conjugated to FITC.

P Type

Mab

Purity

Purified

Isotype

IgG1,k

Additional Info

Recognizes bovine fibrillin (Mr 350kD). Species Crossreactivity: Human.

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