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Fibroblast Growth Factor Receptor 1a (FGFR1 alpha)

Fibroblast Growth Factor Receptor 1a (FGFR1 alpha)

Cat no: F4305-02Q

Supplier: United States Biological
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FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is a widely expressed membrane receptor, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. Applications: Suitable for use in Western Blot, Immunoprecipitation, and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml,10ng recombinant bacterial, baculoviral or native Immunoprecipitation: Native, nuclear, recombinant and ligand-labeled Immunohistochemistry: Frozen sections of human glioblasomas, paraformaldehyde fixed cells and nuclei, human myocardial biopsies Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F4305-02Q
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 250ug
Form: Supplied as a liquid in PBS, pH 7.4. No preservative added.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Xu, et al., (1992), J. Biol. Chem., 267:17792, 2. Proudovsky, et al., (1994), J. Biol. Chem., 269:31720, 3. Morrison, et al., (1994) Cancer Res., 54:2794, 4. Zhao, et al., (1994), J. Clin. Invest., 94:992, 5. Feng, et al., (1996) Biochim. Biophys. Acta., 1310:67.
Additional info: Recognizes the NH2-terminus of unique NH2-terminal Ig loop of human FGFr1a. Epitope is within the sequence between glu30 and ala74 of FGFr1a. Species Crossreactivity: rat and mouse

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