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FOXO1a (FKH1, FKHR, FOXO1, Forkhead Box O1a, Forkhead Homolog1, Forkhead Rhabdomysarcoma)

FOXO1a (FKH1, FKHR, FOXO1, Forkhead Box O1a, Forkhead Homolog1, Forkhead Rhabdomysarcoma)

Cat no: F9049-02C

Supplier: United States Biological
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FKHR (ForKHead in Rhabdomyosarcoma), a 70kD protein, is one member in a subfamily of the forkhead homeotic gene family of transcription factors. Recent experiments have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the carboxyl terminal region of the FKHR protein. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F9049-02C
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ug
Form: As reported
P type: Mab
Isotype: IgG1,k
Purity: Mouse ascites
Alternative names: DAF-16, Forkhead, Drosophila, Homolog of, in Rhabdomyosarcoma
References: 1.Galili, N., et al. (1993) Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Natl Genet 5:230-235. 2.Davis, R.J., et al. (1995) Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma. Hum Mol Genet 4:2355-2362. 3.Anderson, M.J., et al. (1998) Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics 47:187-199. 4.Biggs, et al. (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96:7421-7426. 5.Tang, E.D et al. (1999) Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem 274:16741-16746. 6. Rena, G., et al. Phosphorylation of the transcription factor forkhead family of the FKHR gene and its rearrangment in alveolar rhabdomyosarcoma. Hum Mol. Genet. 4:2355-2362, 1995. 7. Brunet, A., et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell. 96:857-868, 1999.
Additional info: Recognizes human FKHR (ForKHead in Rhabdomyosarcoma), a 70kD protein.

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