Gli-3 (Gli-3, Zinc Finger Protein Gli-3, GLI-Kruppel family member GLI-3)

Supplier:

United States Biological

Cat no: 168213

Gli-3 (Gli-3, Zinc Finger Protein Gli-3, GLI-Kruppel family member GLI-3)

Gli-3 (also known as zinc finger protein Gli-3 or GLI-Kruppel family member GLI-3) belongs to the GLI C2H2-type zinc finger protein family and contains 5 C2H2-type zinc fingers. Gli-3 is very important for normal limb and brain development and is implicated in the transduction of Shh signal. Gli-3 is a nuclear protein expressed in a wide variety of normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium. Defects in Gli-3 are the cause of Greig cephalo-poly-syndactyly syndrome (GCPS); an autosomal dominant disorder-affecting limb and cranio-facial development. Two isoforms of human Gli-3 have been reported. One is the full-length protein at~170-190kD and the other is a truncated isoform at~80kD.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:6000-1:30,000\nWestern Blot: 1:500-1:2000\nImmunohistochemistry: 0.5mg/ml-5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

168213

Size

100ug

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Can, Ch/Bird, NHP, Xen/Amph

Form

Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.

P Type

Pab

Purity

Purified by Protein A/G affinity chromatography.

Isotype

IgG

Additional Info

Recognizes human Gli-3. Species Crossreactivity: chimpanzee, squirrel monkey, xenopus laevis, chicken, canine and quail. Species sequence homology: mouse (94%) and rat (88%).

Alternative Names

Gli-3, Zinc Finger Protein Gli-3, GLI-Kruppel family member GLI-3

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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Collagen Type II (Alpha-1 Type II Collagen, Collagen alpha-1(II) Chain Precursor, Collagen Type II alpha 1 Polypeptide, COL2A1, COL2A1 Protein, Cartilage Collagen, CB11)

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United States Biological

Collagen Type II (Alpha-1 Type II Collagen, Collagen alpha-1(II) Chain Precursor, Collagen Type II alpha 1 Polypeptide, COL2A1, ANFH, AOM, Cartilage Collagen, Chondrocalcin, COL11A3, MGC131516, SEDC)

Applications

ELISA, IHC

Hosts

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Reactivities

Hum

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