Home  >  Products  >  GluR3 (Glutamate Receptor 3, GluR3, GluR-3, AMPA-selective Glutamate Receptor 3, AMPA3, GLURC, GluR-C, GluR-K3, Ionotropic Glutamate Receptor AMPA 3, Gria3, MRX94)
GluR3 (Glutamate Receptor 3, GluR3, GluR-3, AMPA-selective Glutamate Receptor 3, AMPA3, GLURC, GluR-C, GluR-K3, Ionotropic Glutamate Receptor AMPA 3, Gria3, MRX94)

GluR3 (Glutamate Receptor 3, GluR3, GluR-3, AMPA-selective Glutamate Receptor 3, AMPA3, GLURC, GluR-C, GluR-K3, Ionotropic Glutamate Receptor AMPA 3, Gria3, MRX94)

Cat no: G3500-19C

Supplier: United States Biological
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AMPA- (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite- and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4), which assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Post-transcriptional modifications (alternative splicing and nuclear RNA editing) and post-translational modifica- tions (glycosylation, phoshorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs (1). GluR 3 knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP). In contrast, GluR 2/3 double kockout mice are impaired in basal synaptic transmission (2). GluR 3 is implicated in a number of diseases includ-ing autoimmune epilepsy, X-linked mental retardation, Rett
Catalogue number: G3500-19C
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 0.02% sodium azide and 50% glycerol.
P type: Mab
Isotype: IgG
Purity: Purified
References: 1. Palmer, C.L. et al. (2005) Pharmacol Rev 57, 253-77, 2. Meng, Y. et al. (2003) Neuron 39, 163-76, 3. Rembach, A. et al. (2004) J Neurosci Res 77, 573-82.
Additional info: Recongnizes endogenous levels of human total GluR 3 protein. Species crossreactivity: mouse, rat.

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