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HERV (HERV-W_7q21.2 Provirus Ancestral Env Polyprotein, Envelope Polyprotein gPr73, HERV-7q Envelope Protein, HERV-W Envelope Protein, Syncytin, Syncytin-1, Enverin, Env-W, ERVWE1)

Cat no: E2286

HERV (HERV-W_7q21.2 Provirus Ancestral Env Polyprotein, Envelope Polyprotein gPr73, HERV-7q Envelope Protein, HERV-W Envelope Protein, Syncytin, Syncytin-1, Enverin, Env-W, ERVWE1)

HERVs are a class of multiple sclerosis associated retroviruses. Reacts with a replication competent Human Endogenous Retrovirus (HERVW) isolated from placenta. The synthetic peptide sequence used as immunogen is taken from the virus envelope polyprotein sequence. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. The HERVW endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.\n\nApplications: \nSuitable for use in Western Blot and ELISA. Other applications have not been tested.\n\nRecommended Dilution:\nWestern Blot: 1:250-1:500\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability: \nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

E2286

Size

50ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide, before the addition of glycerol to 40%.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Blond, et al., (1999) J. Virol. 73:1175

Additional Info

Recognizes a replication-competent human Endogenous Retrovirus (HERV) isolated from placenta. Recognizes aa42-50 (QRPGNIDAPC) of the HERV protein.

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