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NBL1, Recombinant, Human, aa18-181, His-Tag (Neuroblastoma Suppressor of Tumorigenicity 1, D1S1733E, DAN, DAND1, NB, NO3)

Cat no: 137133

NBL1, Recombinant, Human, aa18-181, His-Tag (Neuroblastoma Suppressor of Tumorigenicity 1, D1S1733E, DAN, DAND1, NB, NO3)

Neuroblastoma suppressor of tumorigenicity 1, also known as NBL1, is a member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. NBL1 is a candidate as a tumor suppressor of neuroblastoma and may play a role in preventing cells from entering the final stage (G1/S) of the transformation process. It is produced in small neurons of the dorsal root ganglion and its expression is activated by MATH-1.\n \nSource: \nRecombinant protein corresponding to human NBL1, fused to His-tag at N-terminal expressed in E.coli.\n\nMolecular Weight: \n~20kD (187aa) (MALDI-TOF)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSAPPPINK LALFPDKSAW CEAKNITQIV GHSGCEAKSI QNRACLGQCF SYSVPNTFPQ STESLVHCDS CMPAQSMWEI VTLECPGHEE VPRVDKLVEK ILHCSCQACG KEPSHEGLSV YVQGEDGPGS QPGTHPHPHP HPHPGGQTPE PEDPPGAPHT EEEGAED\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

137133

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 0.1M NaCl, 10% glycerol, 1mM DTT.

Purity

~90% (SDS-PAGE)

References

1. Kim A S., et al. (2003) Brain Res Dev. 145:159-162. 2. Gerlach Bank L M., et al. (2004) Dev Dyn. 229:219-230.

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