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Notch1 (Notch Homolog Protein 1, hN1, Translocation-associated Notch Protein TAN-1) BSA & Azide Free

Cat no: N5375-06B

Notch1 (Notch Homolog Protein 1, hN1, Translocation-associated Notch Protein TAN-1) BSA & Azide Free

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals, which include notch-1. notch-2, notch-3, and notch-4 (Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of notch-1. Mature notch proteins are heterodimeric receptors derived from the cleavage of notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm). Alteration of notch-1 signaling or expression may contribute to tumorigenesis.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested. \n\nRecommended Dilution: \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n

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SPECIFICATIONS

Catalog Number

N5375-06B

Size

250ul

Applications

FC

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.4. Also available with BSA and azide See N5375-06A

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG2b

Additional Info

Recognizes human Notch 1. Has not been tested for crossreaction with Notch-2. Species Crossreactivity: Mouse.

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