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NRG3, ID (NRG3, Pro-neuregulin-3, membrane-bound isoform, Neuregulin-3) (Azide free) (HRP)

Cat no: 039148-HRP

NRG3, ID (NRG3, Pro-neuregulin-3, membrane-bound isoform, Neuregulin-3) (Azide free) (HRP)

NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.\n\nApplications:\nSuitable for use in Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nImmunohistochemistry: 1:50-100\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze horseradish peroxidase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

039148-HRP

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free). Conjugated to HRP.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

Zhang, D., et al., Proc. Natl. Acad. Sci. U.S.A. 94(18):9562-9567 (1997).

Additional Info

Human

Alternative Names

NRG3, Pro-neuregulin-3, membrane-bound isoform, Neuregulin-3

Read more on Supplier website

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Mouse, Rat

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info
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