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NTS, Recombinant, Human, aa24-170, His-Tag (Neurotensin/Neuromedin N, NMN-125, NN, NT, NT/N, NTS1)

Cat no: 138706

NTS, Recombinant, Human, aa24-170, His-Tag (Neurotensin/Neuromedin N, NMN-125, NN, NT, NT/N, NTS1)

Neurotensin, also known as NTS, is a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. \n\nSource:\nRecombinant protein corresponding to aa24-170 from human NTS at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~19.9kD (172aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSHMSDSEE EMKALEADFL TNMHTSKISK AHVPSWKMTL LNVCSLVNNL NSPAEETGEV HEEELVARRK LPTALDGFSL EAMLTIYQLH KICHSRAFQH WELIQEDILD TGNDKNGKEE VIKRKIPYIL KRQLYENKPR RPYILKRDSY YY\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138706

Size

100ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.

Purity

~90% (SDS-PAGE)

References

1. Bean A.J., et al. (1992) Neuroscience. 50:259-268 2. Quistgaard E.M., et al. (2009) Nat. Struct. Mol. Biol. 16:96-98.

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