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NVP-BEZ235, Free Base (4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethyl-benzeneacetonitrile, BEZ235)

Cat no: N8569-60

NVP-BEZ235, Free Base (4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethyl-benzeneacetonitrile, BEZ235)

NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. NVP-BEZ235 is able to effectively and specifically block the dysfunctional activation of the PI3K pathway and induce G(1) arrest. It also inhibits the growth of human cancer in animal models.\n\nSolubility:\nSoluble in anhydrous dimethylformamide at 10mg/ml after warming to 75C and cooling; soluble in DMSO at 1.33mg/ml with warming; soluble in 1-methyl-2-pyrrolidinone at about 2mg/ml if heated in a 75C bath and cooled; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20uM; buffers, serum or other additives may increase or decrease the aqueous solubility.\n\nMelting Point:\n282.5-285C\n\nElemental Analysis:\nCalculated\nC: 76.74%\nH: 4.94%\nN: 14.92%\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

N8569-60

Size

25mg

Form

Supplied as a white to off-white powder.

Purity

~99%

References

1. Maira, S.M., et al. Mol. Cancer Ther. 7:1851-1863 (2008). 2. Schnell, C.R., et al. Cancer Res. 68:6598-6607 (2008). 3. Eichhorn, P.J., et al. Cancer Res. 68:9221-9230 (2008). 4. Marone, R., et al. Mol. Cancer Res. 7:601-613 (2009). 5. Serra, V., et al. Cancer Res. 68:8022-8030 (2008).

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