Home  >  Products  >  p38alpha, Active, Recombinant, Human (Active p38alpha, p38alpha, p38, p38 alpha, p38a, human P38alpha, active kinase, active kinases, recombinant P38a, recombinant P38, kinase activity assay, protein kinase)
p38alpha, Active, Recombinant, Human (Active p38alpha, p38alpha, p38, p38 alpha, p38a, human P38alpha, active kinase, active kinases, recombinant P38a, recombinant P38, kinase activity assay, protein kinase)

p38alpha, Active, Recombinant, Human (Active p38alpha, p38alpha, p38, p38 alpha, p38a, human P38alpha, active kinase, active kinases, recombinant P38a, recombinant P38, kinase activity assay, protein kinase)

Cat no: 167929

Supplier: United States Biological
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p38a (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines. The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of p38 include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Source: Recombinant protein corresponding to human p38a, expressed in Sf9 insect cells. Molecular Weight: ~67.0kD Biological Activity: The specific activity of p38alpha was determined to be 77nmol/min/mg as per activity assay protocol. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 167929
Size: 5ug
Form: Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Purity: ~90% (SDS-PAGE)
References: 1. Han, J. et al: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994. 2. Ge, B. et al: MAPKK-independent activation of p38-alpha mediated by TAB1-dependent autophosphorylation of p38- alpha. Science 295: 1291-1294, 2002.

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