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p38beta, Active, Recombinant (p38 beta, P38, p38, p38beta, p38b, human P38beta, active kinase, active kinases, recombinant P38beta, recombinant P38b, kinase activity assay, protein kinase)

Cat no: 167930

p38beta, Active, Recombinant (p38 beta, P38, p38, p38beta, p38b, human P38beta, active kinase, active kinases, recombinant P38beta, recombinant P38b, kinase activity assay, protein kinase)

p38-beta is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress. The p38-beta is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. Alternatively spliced transcript variants encoding the same protein have been observed.\n\nSource:\nRecombinant protein corresponding to Active p38 beta expressed in Sf9 insect cells\n\nMolecular Weight: \n~71.0kD\n\nBiological Activity:\nThe specific activity of P38BETA was determined to be 123nmol/min/mg as per activity assay protocol.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

167930

Size

5ug

Form

Supplied as a liquid in 50mM Tris-HCl, pH 7.5,150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Purity

~90% (SDS-PAGE)

References

1.Jiang, Y. et al: Characterization of the structure and function of a new mitogen-activated protein kinase (p38- beta). J. Biol. Chem. 271: 17920-17926, 1996.\n2. Stein, B. et al: p38-2, a novel mitogen-activated protein kinase with distinct properties. J. Biol. Chem. 272: 19509- 19517, 1997.

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