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Serotonin Transporter (SERT, 5HT, 5-hydroxytryptamine)

Cat no: S1001-28

Serotonin Transporter (SERT, 5HT, 5-hydroxytryptamine)

Serotonin (5-hydroxytryptamine), MW 176, is a catecholamine , a monoamine neurotransmitter, found in abundance in the central nervous system, platelets, brain and spinal cord as well as secreted by enterochromaffin cells (EC or Kulchitsky cells, a type of enteroendocrine cell occurring in the epithelia lining the lumen of the gastrointestinal tract) in the stomach, intestines, appendix and in endocrine cells along the gut and in carcinoid tumors. Platelets and mast cells are rich in serotonin. Serotonin plays important physiological functions at the intestinal level. Human intestinal epithelial Caco-2 cellls functionally express SERT both at their apical and basolateral cell membranes. It is a 630aa residue in human (chromosome 17q11), rat and mouse.\n\nThe serotonin transporter (SERT) is a monoamine transporter protein. This protein is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamine, cocaine, and MDMA, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma. SERT reuptakes serotonin in the synaptic cleft and terminates its function. It allows neurons, platelets, and other cells to accumulate the chemical neurotransmitter serotonin, which affects emotions and drives.\n\nNeurons communicate by using chemical messages like serotonin between cells. The transporter protein, by recycling serotonin, regulates its concentration in a gap, or synapse, and thus its effects on a receiving neuron

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SPECIFICATIONS

Catalog Number

S1001-28

Size

100ug

Applications

IHC

Hosts

Mouse

Reactivities

Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

References

1. Molecular and Cellular Neuroscience (1997) 9:170-184. 2. Inazu, M. et al., Neurochemistry International (2001) 39:39-49.

Additional Info

Recognizes Serotonin Transporter. Species Crossreactivity: Rat and mouse.

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