Smoothened (Smoothened Homolog, SMO, SMOH, Gx, HGNC:11119, Protein Gx)

Supplier:

United States Biological

Cat no: S1014-63E

Smoothened (Smoothened Homolog, SMO, SMOH, Gx, HGNC:11119, Protein Gx)

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz:Smo family with 787aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 0.1-1ug/ml\nImmunohistochemistry (paraffin): 10ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nHuman heart lysate and human brain tissue\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S1014-63E

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, NHP

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Chen, W. et al. Science. 306:2257-2260 (2004). 2. Meloni, AR. et al. Mol. Cell. Biol. 26:7550-7560 (2006). 3. Xie, J. et al. Nature. 391:90-92 (1998).

Additional Info

Recognizes human Smoothened Drosophila Homolog (SMOH). Species Crossreactivity: monkey and mouse. Species Sequence Homology: zebrafish

Alternative Names

Smoothened Homolog (Drosophila)

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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