SNX2 (Sorting Nexin 2, Sorting Nexin-2, MGC5204, Transformation-related Gene 9 Protein, TRG9, TRG-9)

Snx2 is a signaling protein belonging to the sorting nexin family and characterized by the presence of a 100aa region known as the phox (PX) homology domain (a phosphoinositide binding domain). As a transport carrier SNX2 is involved in several stages of intracellular trafficking of proteins and also in the EGFR signaling pathway. The retromer complex that is composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2, is required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Though Snx2 associates with formin-binding protein 17, its function is yet unknown. It may form oligomeric complexes with itself as well as with other family members Snx1, Snx1A, and Snx4, but not with Snx3 and is ubiquitously expressed in most tissues, including peripheral leukocytes.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.25-0.5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nMouse placenta lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S1014-97B1

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, NHP

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Rojas, R. et al. Mol. Cell Biol. 27:1112-1124 (2007). 2. Carlton, JG. et al. J. Cell. Sci. 118:4527-4539 (2005). 3. Haft, CR. et al. Molec. Cell. Biol. 18:7278-7287 (1998).

Additional Info

Recognizes human Snx2. Species Crossreactivity: monkey, mouse, rat. Species sequence homology: chicken, bovine, pufferfish, xenopus.