SRC1, exon 12 (Steroid Receptor Coactivator 1, SRC-1, ASV, c-SRC, F-SRC-1, Hin2 Protein, Hin-2 Protein, KAT13A, MGC129719, MGC129720, mNRC-1, Nuclear Receptor Coactivator 1, Nuclear Receptor Coactivator Protein 1, NCOA1, NCoA-1, NY-REN-52 Antigen, p60 Src

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate. One such coactivator is Steroid Receptor Coactivator-1 (SRC 1), a 110kD protein.\n\nSRC 1 has been shown to interact with and stimulate the transcriptional activity of estrogen, progesterone, retinoic acid, thyroid and glucocorticoid receptors, as well as retinoic X receptor (RXR) in a ligand dependent manner. The amino terminal region of SRC 1 contains a PAS-A-basic helix-loop-helix homology domain which has previously been shown to be dimerization domains in other nuclear transcription factors including the aryl hydrocarbon (Ah) receptor and its heterodimerization partner, ARNT. The carboxy-terminal region of SRC 1 has been shown to possess histone acetyltransferase activity specific primarily for histones H3 & H4.\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S6505-05

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

As reported

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Specific for human SRC1 protein. Other species have not been tested. Mouse share 25/29 residues with the peptide used as the immunogen for this antibody.