Survivin

Supplier:

United States Biological

Cat no: S8500-03L

Survivin

Survivin, a member of the inhibitors of apoptosis protein (IAP) family, acts as both an anti-apoptosis and a pro-survival factor. Survivin also mediates embryonic submandibular gland epithelial cell survival. It is prominently expressed in embryonic tissues, overexpressed in nearly all common human cancers, and relatively undetectable in normal human tissue. Survivin is involved in cell proliferation, and also interacts with cyclin-dependent kinase 4 (cdk4). Survivin has been implicated in the regulation of cell cycle regulation, and is also highly expressed during G2/M phases of the cell cycle, downregulated in G1 phase, and localized to the mitotic spindle. Survivin overexpression correlates with tumor progression, and has been shown to be a poor prognostic factor in a variety of solid tumors, including colorectal cancer, hepatocellular carcinoma, lung adenocarcinoma, and esophageal cancer.\n\nApplications:\nSuitable for use in Western Blot, Immunoprecipitation and ELISA. Other applications have not been tested.\n\nRecommended Dilutions:\nWestern Blot: 1-3ug/ml\nImmunoprecipitation (Native): 5-10ug/ IP reaction\nELISA: 0.1-1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nWestern Blot: HEK 293 and HeLa cell lysates. Immunoprecipitation: HEK 293 cell extracts\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S8500-03L

Size

100ug

Applications

ELISA, IP, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A chromatography.

Isotype

IgG1

Additional Info

Recognizes human survivin at~16kD.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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