Synaptophysin

Synaptophysin is an ~38kD integral membrane protein involved in neurotransmitter exocytosis present on synaptic vesicles. This protein consists of four transmembrane domains, with its amino- and carboxyl-terminus facing the cytoplasm. Due to its transmembrane domain structure, synaptophysin has been postulated to be a gap junction-like protein because voltage-dependent channel activity is seen when synaptophysin hexamers are reconstituted into lipid membranes. Recent studies have shown synaptophysin to be a major cholesterol-binding protein in brain synaptic vesicles and it has been proposed that this cholesterol-binding ability may be of key importance in the generation of synaptic vesicles at plasma membranes. A regional reduction of synaptophysin was found in patients with Alzheimer

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SPECIFICATIONS

Catalog Number

S9108-16

Size

100ul

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat, Bov

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified by ammonium sulfate precipitation

Isotype

IgM

References

1. Honer, W.G., Hu, L. and Davies, P., Brain Research 609: 9-20 (1993). 2. Rehm, H., Wiedenmann, B. and Betz, H., EMBO J. 5: 535-541 (1986). 3. Thomas, L., et al., Science 242: 1050-1053 (1988). 4. Thiele, C., et al., Nat. Cell Biol. 2: 42-49 (2000). 5. Martin, T.F., Nat. Cell Biol. 2: E9-E11 (2000). 6. Landen, M., et al., Biol. Psychiatry 46: 1698-1702 (1999). 7. Honer, W., et al., Neurobiol. Aging 13: 373-382 (1992).

Additional Info

Recognizes human synaptophysin at ~38kD. \nSpecies Crossreactivity: mouse, rat and bovine. No reactivity was detected in mouse liver extracts.