Synaptophysin (SYP, SYPH, SypI, Major Synaptic Vesicle Protein P38, Syn p38)

Staining of normal neuroendocrine and neoplastic neuroendocrine cells in tissue sections. The antibody recognizes presynaptic vesicles of neurons of brain, spinal cord, retina neuromuscular junctions, small vesicles of adrenal medulla and pancreatic islets. The antibody can be used for the characterisation of neuroendocrine tumors.\n\nApplications: \nSuitable for use in Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: Adrenal pheochromocytoma and pancreatic islet cell neoplasm\n\nCellular Localization: Integral membrane protein. Synaptic vesicles.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S9108-03H

Size

1.2ml

Applications

IHC

Hosts

Mouse

Reactivities

Mouse, Rat, Bov

Form

Ascitic fluid with 0.1% sodium azide

P Type

Mab

Purity

Ascites

Isotype

IgG1

References

This product has been used in:Wiedenmann B & Franke WW Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 41:1017-28 (1985). <PUBMED:3924408>

Additional Info

The antibody is specific for Synaptophysin. The specificity was ascertained by immunoblotting and immunohistochemistry. Species Crossreactivity: Bovine, mouse and rat.