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Synaptotagmin I (SYT1, DKFZp781D2042, p65, P65, SVP65, Synaptotagmin-1, SYT, SytI)

Synaptotagmin I (SYT1, DKFZp781D2042, p65, P65, SVP65, Synaptotagmin-1, SYT, SytI)

Cat no: S9109-19A

Supplier: United States Biological
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The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:2000 Western Blot: 0.3-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Brain (hippocampus) and Mouse and Rat Brain lysates Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Peptide Blocking: Corresponding peptide is available for Peptide Blocking studies. See S9109-19A-P. Antibody
Catalogue number: S9109-19A
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Martens S, Kozlov MM, McMahon HT. How synaptotagmin promotes membrane fusion. Science. 2007 May 25;316(5828):1205-8. Epub 2007 May 3
Additional info: Recognizes human Synaptotagmin I at ~65kD. Species sequence homology: mouse, rat, canine, bovine.

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