TAB1, ID (Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1, TGF-beta-activated Kinase 1-binding Protein 1, TAK1-binding Protein 1, MAP3K7IP1, TGF-beta-activated Kinase 1 And MAP3K7-binding Protein 1)

TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-b and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-b, demonstrating how this protein can function as a mediator between TGF-b receptors and TAK1.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5-1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\n3T3 cell lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

T0291-85N

Size

50ug

Applications

ELISA, ICC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Shibuya, H. et al. Science 272, 1179(1996). 2. Irie, T. et al. FEBS Lett. 467, 160 (2000). 3. Akira, S. et al. Nat. Rev. Immunol. 4, 499 (2004). 4. Jiang, Z. et al. Mol. Cell Biol. 22, 7158 (2002). 5. Cheung, PC. et al. Biochem J. 378, 27 (2004). 6. Ono, K. et al. Biochem. Biophys. Res. Commun. 307, 332 (2003).

Additional Info

Recognizes human TAB1. Species Crossreactivity: mouse.