TAP2, CT (Antigen Peptide Transporter 2, APT2, Peptide Transporter TAP2, ATP-Binding Cassette Sub-family B Member 3, Peptide Supply Factor 2, Peptide Transporter PSF2, PSF-2, Peptide Transporter Involved In Antigen Processing 2, Really Interesting New Gen

The membrane-associated protein TAP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The TAP2 gene is located 7 kb telomeric to gene family member ABCB2. ThTAP2 is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.\n\nApplications: \nSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nImmunohistochemistry: 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

T8266-06-AP

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Alkaline Phosphatase.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1.Strausberg, R.L., et al., Proc. Natl. Acad. Sci. USA 99(26):16899-16903 (2002). 2.Tang, J., et al., Genes Immun. 2(1):32-40 (2001). 3.Kumagai, S., et al., Arthritis Rheum. 40(9):1685-1692 (1997). 4.Beck, S., et al., J. Mol. Biol. 255(1):1-13 (1996). 5.Cano, P., et al., Tissue Antigens 45(2):139-142 (1995).

Additional Info

Recognizes human TAP2.