TNC (Hxb, Hexabrachion, Tenascin-C, TN-C, TN, CYTOTACTIN, hexabrachion (tenascin C, cytotactin), hexabrachion (tenascin), MGC167029)

TNC (Tenascin C), also known as TN or HXB, is a protein that in humans is encoded by the TNC gene. By means of Southern analysis of rodent-human somatic cell hybrids and by in situ hybridization using hexabrachion cDNA probes, Gulcher et al. (1990) localized the TNC gene to chromosome 9q32-q34. Olson and Srivastava (1996) reviewed processes involved in separation of the cardiac tube into the atria, ventricles, and outflow tract. They noted that tenascin is upregulated and NCAM is downregulated in the embryonic endocardial cushions. Gherzi et al. (1997) found that the TNC gene is subject to transcriptional control by OTX2.\n\nUniProt Number:\nQ80YX1\n\nGene ID:\nTNC\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry (Paraffin).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

145286

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Gherzi, R., Briata, P., Boncinelli, E., Ponassi, M., Querze, G., Viti, F., Corte, G., Zardi, L. The human homeodomain protein OTX2 binds to the human tenascin-C promoter and trans-represses its activity in transfected cells. DNA Cell Biol. 16: 559-567, 1997.\n2. Gulcher, J. R., Alexakos, M. J., Le Beau, M. M., Lemons, R. S., Stefansson, K. Chromosomal localization of the human hexabrachion (tenascin) gene and evidence for recent reduplication within the gene. Genomics 6: 616-622, 1990. \n3. Olson, E., Srivastava, D. Molecular pathways controlling heart development. Science 272: 671-676, 1996.\n

Additional Info

Recognizes human,mouse and rat TNC. No crossreactivity with other proteins.