Home  >  Products  >  TRIB3 (Tribbles Homolog 3, TRB-3, Neuronal Cell Death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappa-B, C20orf97, NIPK, SKIP3, TRB3)
TRIB3 (Tribbles Homolog 3, TRB-3, Neuronal Cell Death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappa-B, C20orf97, NIPK, SKIP3, TRB3)

TRIB3 (Tribbles Homolog 3, TRB-3, Neuronal Cell Death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappa-B, C20orf97, NIPK, SKIP3, TRB3)

Cat no: T8335-43H

Supplier: United States Biological
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A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human liver lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8335-43H
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Wu,M., Xu,L.G., Zhai,Z. and Shu,H.B. SINK is a p65-interacting negative regulator of NF-kB-dependent transcription. J. Biol. Chem. 278 (29), 27072-27079 (2003). 2. Du,K., Herzig,S., Kulkarni,R.N. and Montminy,M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300 (5625), 1574-1577 (2003). 3. Bowers,A.J., Scully,S. and Boylan,J.F. SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. Oncogene 22 (18), 2823-2835 (2003). 4. Kiss-Toth,E., Bagstaff,S.M., Sung,H.Y., Jozsa,V., Dempsey,C., et al. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J. Biol. Chem. 279 (41), 42703-42708 (2004).
Additional info: Recognizes human TRIB3. Species sequence homology: monkey, canine.

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