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UCH-L3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3, Ubiquitin thioesterase L3, UCHL3)

UCH-L3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3, Ubiquitin thioesterase L3, UCHL3)

Cat no: U1005-01K

Supplier: United States Biological
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UCH-L3 is a 26kD thiol protease that hydrolyses a peptide bond in ubiquitin and nedd8. UCH-L3 and the closely related UCH-L1 are thought to recycle ubiquitin to maintain pools of monomeric ubiquitin necessary for proteolysis. UCH-L1 and UCH-L3 have been shown to have separate and overlapping functions in the maintanence of neurons of the gracile tract, nucleus tractus solitarius (NTS) and area postrema (AP). A recent paper has shown that UCH-L3 defective mice have a learning deficit compared to wild type littermates, and significantly increased working memory errors. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 5-15ug/ml Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1005-01K
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Kurihara, L.J. et al. (2001) Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Hum. Mol. Genet. 10: 1963-1970. 2. Wood, M.A. et al. (2005) Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory. Hippocampus. 15: 610-621.
Additional info: Recognizes an epitope within the internal domain of human ubiquitin C-terminal hydrolase L3 (UCH-L3). Species sequence homology: rat, mouse.

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