ULBP2, ID (ULBP2, N2DL2, RAET1H, NKG2D ligand 2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2) (FITC)

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze FITC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

043592-FITC

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to FITC.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

McGilvray, R.W., et al. Int. J. Cancer 127(6):1412-1420(2010)\nNuckel, H., et al. Leukemia 24(6):1152-1159(2010)\nAntoun, A., et al. Hum. Immunol. 71(6):610-620(2010)\nDavila, S., et al. Genes Immun. 11(3):232-238(2010)\nWard, J., et al. PLoS Pathog. 5 (10), E1000613 (2009) :

Additional Info

Human

Alternative Names

ULBP2, N2DL2, RAET1H, NKG2D ligand 2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2