USP6, NT (Ubiquitin Carboxyl-terminal Hydrolase 6, Ubiquitin Thiolesterase 6, Ubiquitin-specific-processing Protease 6, Deubiquitinating Enzyme 6, Proto-oncogene TRE-2, HRP1, TRE2)

Supplier:

United States Biological

Cat no: U4099-97A

USP6, NT (Ubiquitin Carboxyl-terminal Hydrolase 6, Ubiquitin Thiolesterase 6, Ubiquitin-specific-processing Protease 6, Deubiquitinating Enzyme 6, Proto-oncogene TRE-2, HRP1, TRE2)

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.\n\nApplications: \nSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nImmunohistochemistry: 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

U4099-97A

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1.Paulding, C.A., et al., Proc. Natl. Acad. Sci. USA 100(5):2507-2511 (2003). 2.Papa, F.R., et al., Nature 366(6453):313-319 (1993). 3.Nakamura, T., et al., Oncogene 7(4):733-741 (1992).

Additional Info

Recognizes human USP6.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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Hosts

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