Home  >  Products  >  USP6 (Ubiquitin Carboxyl-terminal Hydrolase 6, Deubiquitinating Enzyme 6, Proto-oncogene TRE-2, Ubiquitin Thiolesterase 6, Ubiquitin-specific-processing Protease 6, HRP1, TRE2)

USP6 (Ubiquitin Carboxyl-terminal Hydrolase 6, Deubiquitinating Enzyme 6, Proto-oncogene TRE-2, Ubiquitin Thiolesterase 6, Ubiquitin-specific-processing Protease 6, HRP1, TRE2)

Cat no: U4099-97B


Supplier: United States Biological
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Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: >1:16,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U4099-97B
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Paulding CA, Ruvolo M, Haber DA. The Tre2 (USP6) oncogene is a hominoid-specific gene. Proc Natl Acad Sci USA. 2003 Mar 4;100(5):2507-11. PMID: 12604796.
Additional info: Recognizes USP6. Species sequence homology: human.

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