VANGL1 (Van Gogh-like Protein 1, Vang-like Protein 1, KITENIN, Loop-tail Protein 2 Homolog, LPP2, MGC5338, Strabismus 2, STB2, STBM2)

Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh:Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal ser/thr -X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 3-5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHCT-116 and RAW cell lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

V2065-50

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Katoh, M. et al. Int. J. Oncol. 20:993-998 (2002). 2. Yagyu, R. et al. Int. J. Oncol. 20:1173-1178 (2002). 3. Kibar, ZN. et al. Engl. J. Med. 356:1432-1437 (2007). 4. Jiri, K. et al. J. Biol. Chem. 281:6434-6441 (2006).

Additional Info

Recognizes human Vang-like 1. Species sequence homology: mouse.

Alternative Names

Vang-like 1 (Van Gogh, Drosophila)