VANGL2 (Van Gogh-like Protein 2, Vang-like Protein 2, KIAA1215, Loop-tail Protein 1 Homolog, LPP1, MGC119403, MGC119404, LTAP, Strabismus 1, STB1, STBM1, STBM)

Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521aa protein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-dishevelled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumour suppressor. It is predominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32,000\nWestern Blot: 0.3-1ug/ml, observed in human lung and mouse brain lysates on ~55kD bands\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

V0499-17A

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Mouse, Bov, ZF/Fish

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Kibar Z, Vogan KJ, Groulx N, Justice MJ, Underhill DA, Gros P. Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet. 2001 Jul;28(3):251-5.

Additional Info

Recognizes human VANGL2. Species Crossreactivity: Mouse. Species sequence homology: Bovine and zebrafish.