VEGFR2 is a receptor for vascular endothelial growth factor (VEGF). VEGF is a potent and unique angiogenic protein that induces endothelial cell (EC) proliferation, EC migration, and vascular permeability, and acts as a crucial survival factor for endothelial cells. In adult cells, the mitogenic and chemotactic effects of VEGF appear mainly to be mediated by VEGFR-2. The activation of VEGFR-2 induces dimerization and transphosphorylation of the receptors, followed by tyrosine phosphorylation and activation of several downstream substrates. It localizes in the 4q11-q12 region of chromosome. VEGFR2 has been reported in Human bone marrow, heart, hematopoietic stem cell, mammary gland, placenta and testis.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Breast carcinoma
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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