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WASP, Neural (N-WASP, Neural Wiskott-Aldrich Syndrome Protein, DKFZp779G0847, MGC48327, WASL)

WASP, Neural (N-WASP, Neural Wiskott-Aldrich Syndrome Protein, DKFZp779G0847, MGC48327, WASL)

Cat no: W0800-01D

Supplier: United States Biological
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Members of the Wiskott-Aldrich syndrome protein (WASP) family regulate the formation of actin-based cell structures in many cell types. These proteins contain C-terminal actin binding domains that can stimulate actin polymerization. In addition, these proteins bind the ARP2/3 complex, which can nucleate actin polymerization at sites that lead to branched actin structures. WASP is expressed primarily in hematopoietic cells, while its homolog N-WASP is widely expressed. These proteins have 48% identity in human with the highest homology in the functional regions of these proteins. Serine and tyrosine phosphorylation regulates the activity of both proteins. WASP is observed as a ~63kD protein in hematopoietic cells, while N-WASP is observed as a ~65kD in many tissues, especially brain. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: W0800-01D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Pab
Purity: Serum
References: 1. Prehoda, K. E. et al., (2000). Science. 290: 801-806. 2. Rohatgi. R. et al., (1999). Cell. 97(2):221-231. 3. Miki, H. et al., (1998). Nature 391: 93-96. 4. Fukuoka, M. et al., (1997). Gene 196: 43 -48. 5. Miki, H. et al., (1996). EMBO J. 15: 5326-5335.
Additional info: Recognizes human N-WASP. Species Crossreactivity: mouse and rat.

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