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ZO-3, aa754-898 (Tight Junction-associated Polypeptide, Zonula Occludens 3)

Cat no: Z0770

ZO-3, aa754-898 (Tight Junction-associated Polypeptide, Zonula Occludens 3)

Tight junctions (or zonula occludens) are selective, semi-permeable barriers in the paracellular pathway of vertebrate endothelia and epithelia. Tight junctions also serve to physically separate functionally and biochemically distinct regions of the plasma membrane that exist in distinct physiological compartments.(1) ZO-1, ZO-2, ZO-3 and occludin are major components of vertebrate tight junctions. ZO-1 is a peripheral (non-transmembrane) membrane protein found on the cytoplasmic leaflet of tight junctions. ZO-1 has a MW of 225kD and is found in two isoforms that differ by the presence or absence of an 80 amino acid region known as

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SPECIFICATIONS

Catalog Number

Z0770

Size

100ug

Applications

ICC, IF, WB

Hosts

Rabbit

Reactivities

Can

Form

Supplied as a liquid in PBS, pH 7.2, 1% BSA, 0.1% sodium azide.

P Type

Pab

Purity

Purified IgG

Isotype

IgG

References

Haskins, et al., J. Cell Biology (1998) 141:199

Additional Info

ZO-3 a 130kD protein which co-immunoprecipitates with the tight junction protein ZO-1of canine MDCK cell line.

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