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Two forms of interleukin-1, designated IL-1alpha and IL-1beta, have been described. Although encoded by distinct genes and exhibiting roughly only 25%...
CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating...
Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2...
Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2...
Pancreatic polypeptide (PP), neuropeptide Y (NPY), and peptide YY (PYY) are related 36-amino acid hormones. A number of structurally related receptors for...
A gene on chromosome 4q31 encodes a 381 amino acid protein, NPY2-R(also designated Neuropeptide Y receptor Y2). NPY2-R is a member of the Gprotein-coupled...
The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the superfamily of guanine nucleotide-binding regulatory protein (G protein)-coupled...
The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor...
The melanocortin family comprises the alpha-, beta- and gamma -melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these...
MC4 receptor is the fourth member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors...
The mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically...
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30 amino acid non-C-terminally...
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The Frizzled 5 protein is...
FZD3 (Frizzled 3) belongs to the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt proteins. Most frizzled...
G protein coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. G...
FIRE is a 689 amino acid protein that maps to human gene EMR4. FIRE is also known as EGF-like module-containing mucin-like hormone receptor-like 4 and is a...
The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators,...
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators,...
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators,...
EDG3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are eight...
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