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Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption...
Members of the Ras superfamily of small GTP-binding proteins are critical mediators of diverse cell signaling pathways, including those leading to cell...
Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins which inhibit positive...
Activation of FUSE, the far-upstream element, is required for the proper expression of the mammalian gene c-myc. The binding of FBP (FUSE-binding protein) to...
Diacylglycerol (DAG) influences numerous cell signaling cascades by functioning as an intracellular, allosteric activator of protein kinase C (PKC), and as a...
A proliferation-inducing ligand (APRIL), also designated TNFSF13, is a Type II membrane protein that shares characteristics with other members of the tumor...
The transcription of many RNA polymerase II-dependent genes requires Spt3, a member of the S. cerevisiae SAGA complex. Transcription from delta sequences,...
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signaling between transcriptional...
Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion,...
Dyskerin (NAP57) associates with the chaperone protein Nopp140 and forms a small ribonucleoprotein particle with GAR1 (NOLA1), NHP2 (NOLA2) and Nop10 for the...
Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH)...
Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is...
Dlx genes are a highly conserved family of six different (Dlx1-6) homeo boxcontaining genes that share homology with distal-less (Dll), a gene expressed in...
The HMG-box protein-1 (HBP1) is a member of the HMG family of transcription factors, which are characterized by the presence of a conserved protein motif,...
ST18 (suppression of tumorigenicity 18), also known as ZNF387 ((zinc finger protein 387), is a 1,047 amino acid nuclear protein that is expressed at low...
The Eph subfamily represents the largest group of receptor protein kinases identified to date. There is increasing evidence that Eph family members are...
The autoimmune regulator gene, which is defective in the hereditary autoimmune disease APECED, encodes the transcriptional activator AIRE. AIRE is expressed...
AKAP 10 (A kinase anchor protein 10), also known as PRKA10 or D-AKAP2 (dual-specific A kinase-anchoring protein 2), is a 662 amino acid mitochondrial...
The T-box (TBX) motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene...
Mixed lineage kinases (MLKs) are a family of protein kinases sharing two leucine zipper-like motifs which mediate protein dimerization, and a kinase domain...
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