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Parathyroid hormone (PTH), which is also designated parathyrin, is an 84 amino acid single chain peptide that functions to regulate calcium meta-bolism by...
The 26S proteasome is a highly ordered proteinase complex consisting of a 20S core and a 19S regulator. While the core is responsible for the proteolytic...
The proteasome represents a large protein complex that exists inside all eukaryotes and archaea, and in some bacteria. The main function of proteasomes is to...
The saposin family includes four structurally related activator proteins, saposin A, B, C and D, that are cleaved from the single precursor protein...
Protein S (PROS) is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein C (APC) and facilitates...
Protein C is a vitamin K-dependent plasma protein that is produced in the liver and made up of two polypeptide chains. It is an important anti-coagulant...
The anterior pituitary secretes a variety of hormones that are involved in cell growth, differentiation and development. Prolactin, a 226 amino acid protein,...
Mitogen Activated Protein Kinase Kinase 7 (MEK 7 or MKK 7) is a 38 kDa member of a tyrosine/threonine protein kinase family that activates the c Jun...
c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through...
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and...
Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene...
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of...
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of...
Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are...
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions...
PPA1 (Pyrophosphate phospho-hydrolase 1), also known as IOPPP (inorganic pyrophosphatase), PP1, PP or PPase, belongs to the PPase family of inorganic...
Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the...
Paroxon is an organophosphorus anticholinesterase compound, used topically in the treatment of glaucoma. It is produced in vivo in mammals by microsomal...
RPB1 is a subunit of RNA polymerase II which catalyses transcription of RNA from DNA. RPB1 forms the polymerase active center together with the second...
Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer due to deficiencies...
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