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Direct IAP-binding protein with low pI / second mitochondria-derived activator of caspase (Smac / DIABLO) promotes apoptosis by activating caspases in the...
The cyclin-dependent kinase 4 inhibitor A (CDK4I or p16-INK4) acts as a negative regulator of the proliferation of normal cells by interacting strongly with...
Secreted protein acidic and rich in cysteine (SPARC) regulates cell growth through interactions with the e, Xenopus/Amphibian,tracellular matri,...
Fibulin-1 is incorporated into fibronectin-containing matri, Xenopus/Amphibian, fibers. Fibulin-1 plays a role in cell adhesion and migration along protein...
NF-kappa-B p50 subunit (NFKB p50) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological...
Connective tissue growth factor (CTGF) is a major connective tissue mitoattractant secreted by vascular endothelial cells. CTGF promotes proliferation and...
Cyclin-dependent kinase inhibitor p27 (p27) is a regulator of cell cycle progression. p27 is involved in G1 arrest. P27 is a potent inhibitor of cyclin E-...
Nucleoside diphosphate kinase A (NDP kinase A) plays a role in the synthesis of nucleoside triphosphates other than ATP. NDP kinase A possesses...
Integrin alpha-3 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3 is involved in endothelial cell...
Integrin alpha-4/beta-7 (integrin beta-7) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT)....
MDM2 mediates ubiquitination of p53/TP53, leading to its degration by the proteasome. MDM2 inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and...
Activin receptor type-2B (ACTR-IIB), upon ligand binding, forms a receptor comple, Xenopus/Amphibian, consisting of two type II and two type I transmembrane...
Angiopoietin-related protein 1 (ANGPTL1) is a member of the vascular endothelial growth factor family. Angiopoietins are the only known growth factors...
Tumor necrosis factor ligand superfamily member 11 (CD254) is a cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. CD254 augments the ability of...
Fibronectin is an adhesive glycoprotein with a molecular mass of 440 kDa. It is believed to be important for the formation of a provisional matri,...
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine. MIF is involved in the innate immune response to bacterial pathogens. The e,...
HSP-90 alpha is a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell...
Factor VIII, along with calcium and phospholipids, acts as a cofactor for factor I, Xenopus/Amphibian,a when it converts factor , Xenopus/Amphibian, to the...
Glucagon plays a key role in glucose metabolism and homeostasis: It regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis, is a...
TNF-beta is a cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. Genetic variations in TNF-beta are a cause of...
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