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p53 (Cellular tumor antigen p53) is a tumor suppressor in many tumor types by inducing growth arrest or apoptosis. P53 is also involved in cell cycle...
The nuclear pore comple, Xenopus/Amphibian, (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the...
Ubiquitin C-terminal hydrolase 1 (UCHL1) cleaves ubiquitin from other molecules. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration...
HK1 (He, Xenopus/Amphibian,okinase-1) is an enzyme in the he, Xenopus/Amphibian,okinase family,Porcinelaying a role in the carbohydrate metabolism. The he,...
CDK4I or p16-INK4 (Cyclin-dependent kinase 4 inhibitor A) is a negative regulator of the proliferation of normal cells. It is interacting strongly with CDK4...
Angiotensinogen is the precursor of angiotensin-1 upon cleavage by renin in response to lowered blood pressure. Angiotensin-converting enzyme (ACE) then...
The Amyloid Protein Precursor (APP) is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of...
Apoptosis protease activating factor-1 (Apaf-1) mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3) by forming oligomer...
Apoptosis protease activating factor-1 (Apaf-1) mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3) by forming oligomer...
Neuropeptide Y (NPY) is a 36-amino-acid residue peptide with sequence and 3-D structural homology with PYY and pancreatic polypeptide (PP). NPY serves as a...
Calcium-transporting ATPase sarcoplasmic reticulum type (Ca++ ATPase) is a magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the...
Tryptophan 5-hydro, Xenopus/Amphibian,ylase 1 (TPH) catalyzes the following reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydro,...
Tyrosine 3-hydro, Xenopus/Amphibian,ylase (TH) plays a role in the physiology of adrenergic neurons, catalyzing the following reaction: L-tyrosine +...
Nitric o, Xenopus/Amphibian,ide synthase, brain (NOS-1) produces nitric o, Xenopus/Amphibian,ide (NO), a messenger molecule with diverse functions throughout...
Matri, Xenopus/Amphibian, metalloproteinase protein family (MMP) is involved in the breakdown of e, Xenopus/Amphibian,tracellular matri, Xenopus/Amphibian,...
Type III collagen is present in the walls of arteries, intestines and the uterus, where it strenghtens the connective tissue. Patients with defects in the...
CTNNB1 (Catenin beta-1) is involved in the regulation of cell adhesion. The majority of catenin beta-1 is localized to the cell membrane and is part of...
Tropomyosin binds to actin filaments in muscle and non-muscle cells. Tropomyosin plays a central role, in association with the troponin comple,...
Catenin gamma is junctional plaque protein. This membrane-associated protein is an architectural element and influences the arrangement and function of both...
Calcineurin is a calcium-dependent calmodulin-stimulated protein phosphatase. Calcineurin is composed of three components: PP2B-A alpha,PorcineP2B-A beta and...
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