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United States Biological

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17-AAG (17-allylamino-17-demethoxygeldanamycin, Telatinib, Tanespimycin, NSC-330507, CNF-101, KOS-953, GLD-36, CP 127374)
17-AAG (17-allylamino-17-demethoxygeldanamycin, Telatinib, Tanespimycin, NSC-330507, CNF-101, KOS-953, GLD-36, CP 127374)
United States Biological

Semi-synthetic derivative of geldanamycin, demonstrating greater stability and lower in vivo toxicity than its parent compound. 17-AAG binds specifically to...

A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile)
A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile)
United States Biological

A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an alpha beta gamma heterotrimer and plays an important role in...

A77 1726-d4 (N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide-d4, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide-d4, LEF-M-d4)
A77 1726-d4 (N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide-d4, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide-d4, LEF-M-d4)
United States Biological

The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with...

A77 1726 (N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M)
A77 1726 (N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M)
United States Biological

The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with...

A 83-01 (3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide)
A 83-01 (3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide)
United States Biological

A selective inhibitor of TGF-beta type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and...

Cortactin, phosphorylated (Tyr466) (Src Substrate Cortactin, EMS1, Amplaxin, CTTN, Oncogene EMS1)
Cortactin, phosphorylated (Tyr466) (Src Substrate Cortactin, EMS1, Amplaxin, CTTN, Oncogene EMS1)
United States Biological

Cortactin is a c-src substrate associated with sites of dynamic actin assembly at the leading edge of migrating cells promotes branched actin filament...

Zyxin (ZYX, ZYX Protein, Zyxin 2, Zyxin-2, ESP-2, HED-2)
Zyxin (ZYX, ZYX Protein, Zyxin 2, Zyxin-2, ESP-2, HED-2)
United States Biological

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal...

Zyxin (ZYX, ZYX Protein, Zyxin 2, Zyxin-2, ESP-2, HED-2)
Zyxin (ZYX, ZYX Protein, Zyxin 2, Zyxin-2, ESP-2, HED-2)
United States Biological

Zyxin, a cytosolic protein containing 3 LIM zinc-binding domains, associates with the actin cytoskeleton near the adhesion plaques. Zyxin localizes to stress...

Zyxin (ZYX, ZYX Protein, Zyxin 2, Zyxin-2, ESP-2, HED-2)
Zyxin (ZYX, ZYX Protein, Zyxin 2, Zyxin-2, ESP-2, HED-2)
United States Biological

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal...

ZW10 Interactor 1 (ZW10-interacting Protein 1, ZWINT 1, ZWINT1, ZWINT-1, ZW10 Interactor, ZWINT, Human ZW10 Interacting Protein 1, HZwint 1, HZwint-1, KNTC2AP, MGC117174)
ZW10 Interactor 1 (ZW10-interacting Protein 1, ZWINT 1, ZWINT1, ZWINT-1, ZW10 Interactor, ZWINT, Human ZW10 Interacting Protein 1, HZwint 1, HZwint-1, KNTC2AP, MGC117174)
United States Biological

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore...

ZU5 (ZU5 and Death Domain Containing Inhibitor of NF-kB, ZU5 and Death Domain-containing Protein, ZUD, MGC34763, Unc-5 Homolog C (C. elegans)-like, UNC5CL)
ZU5 (ZU5 and Death Domain Containing Inhibitor of NF-kB, ZU5 and Death Domain-containing Protein, ZUD, MGC34763, Unc-5 Homolog C (C. elegans)-like, UNC5CL)
United States Biological

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural...

ZU5 (ZU5 and Death Domain Containing Inhibitor of NF-kB, ZU5 and Death Domain-containing Protein, ZUD, MGC34763, Unc-5 Homolog C (C. elegans)-like, UNC5CL)
ZU5 (ZU5 and Death Domain Containing Inhibitor of NF-kB, ZU5 and Death Domain-containing Protein, ZUD, MGC34763, Unc-5 Homolog C (C. elegans)-like, UNC5CL)
United States Biological

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural...

ZU5 (ZU5 and Death Domain Containing Inhibitor of NF-kB, ZU5 and Death Domain-containing Protein, ZUD, MGC34763, Unc-5 Homolog C (C. elegans)-like, UNC5CL)
ZU5 (ZU5 and Death Domain Containing Inhibitor of NF-kB, ZU5 and Death Domain-containing Protein, ZUD, MGC34763, Unc-5 Homolog C (C. elegans)-like, UNC5CL)
United States Biological

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural...

ZSCAN21 (Zinc Finger and SCAN Domain Containing 21, DKFZp434L134, NY-REN-21, Zipro1)
ZSCAN21 (Zinc Finger and SCAN Domain Containing 21, DKFZp434L134, NY-REN-21, Zipro1)
United States Biological

Applications: Suitable for use in Western Blotting. Other applications not tested. Recommended Dilution: Western Blotting: 1:1000-1:2000 Optimal dilutions to...

ZRANB1 (Zinc Finger Ran-binding Domain-containing Protein 1, DKFZp762P2216, Ubiquitin Thioesterase ZRANB1, TRABID, hTrabid)
ZRANB1 (Zinc Finger Ran-binding Domain-containing Protein 1, DKFZp762P2216, Ubiquitin Thioesterase ZRANB1, TRABID, hTrabid)
United States Biological

Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative...

Zonulin
Zonulin
United States Biological

Zonulin is a protein that participates in tight junctions between cells of the wall of the digestive tract. Initially discovered in 2000 as the target of...

ZO-1 (Tight Junction-associated Polypeptide, Zonula Occludens 1)
ZO-1 (Tight Junction-associated Polypeptide, Zonula Occludens 1)
United States Biological

Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many...

ZO3, CT (Tight Junction Protein ZO-3, Tight Junction Protein 3, Zona Occludens Protein 3, Zonula Occludens Protein 3, TJP3 )
ZO3, CT (Tight Junction Protein ZO-3, Tight Junction Protein 3, Zona Occludens Protein 3, Zonula Occludens Protein 3, TJP3 )
United States Biological

Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin-fixed,...

ZO-2 (Tight Junction-associated Polypeptide, Zonula Occludens 2)
ZO-2 (Tight Junction-associated Polypeptide, Zonula Occludens 2)
United States Biological

Human zona occludens 2 (ZO-2), an ~160kD tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family...

ZONA OCCLUDENS 1 alpha-minus (ZO-1 alpha-minus)
ZONA OCCLUDENS 1 alpha-minus (ZO-1 alpha-minus)
United States Biological

Human zona occludens 1 (ZO-1), an ~220kD tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family...

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