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HNF-1 ((alpha) and (beta)), HNF-3 ((alpha), (beta) and (gamma)), HNF-4 ((alpha) and (gamma)), and HNF-6 compose, in part, a homoeprotein family designated...
BUD31 (protein G10 homolog, EDG-2) is a 144 amino acid protein encoded by the human gene BUD31. BUD31 is a nuclear protein that belongs to the BUD31 (G10)...
Members of the transforming growth factor (beta) superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain...
DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases. In DNA replication, these...
Members of the transforming growth factor (beta) superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain...
T-cell factor-1 (TCF-1) is a DNA-binding transcriptional activator that isessential for lymphoid cell development. The TCF family of transcription factors...
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the...
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the...
The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and (alpha)-actinins. There are four...
The catenins, (alpha), (beta) and (gamma), are proteins which bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the...
(beta)-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic...
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the...
CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and...
AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2...
Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds...
The role of transcription factors in the regulation of gene expression is well established. Although the activity of these factors can be regulated by...
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus...
c-TAK1 (Cdc25C associated protein kinase) phosphorylates Cdc25C on Ser 216 and is ubiquitously expressed in various human tissue and cell lines. C-TAK1 is...
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and...
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the...
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