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DNA topoisomerase 1 (TOP1) catalyzes the conversion of one topological isomer of DNA to another. A chromosomal aberration involving TOP1 is found in a form...
Breast cancer type 2 susceptibility protein (BRCA2) is involved in double-strand break repair and homologous recombination as well as in S phase checkpoint...
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related...
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS1) cleaves aggrecan, a cartilage proteoglycan. ADAM-TS1 is an active metalloprotease...
Solute carrier family 2, facilitated glucose transporter member 3 (GLUT3) is a facilitative glucose transporter and is theorized to be a neuronal glucose...
Rho-associated, coiled-coil-containing protein kinase 2 (ROCK-2) regulates the assembly of the actin cytoskeleton. ROCK-2 promotes the formation of stress...
P2Y1 is a receptor for e, Xenopus/Amphibian,tracellular adenine nucleotides such as ATP and ADP. In platelets,Porcine2Y1 binding to ADP leads to mobilization...
DNA topoisomerase 2-alpha (TOP2A) is involved in the control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands....
TNFRSF1A-associated via death domain (TRADD) is an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated...
Paired bo, Xenopus/Amphibian, protein Pa, Xenopus/Amphibian,-8 (Pa, Xenopus/Amphibian,-8) is a transcription factor involved in thyroid-specific gene e,...
Oligodendrocyte-myelin glycoprotein (OMG) is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous...
Toll-like receptor 5 (TLR5) participates in the innate immune response to microbial agents. TLR5 mediates detection of bacterial flagellins. TLR5 acts via...
Proteinase-activated receptor 4 (PAR-4) is a receptor for activated thrombin or trypsin. PAR-4 is coupled to G proteins that stimulate phosphoinositide...
Interleukin-23 (IL-23) is a heterodimer cytokine composed of IL-23-alpha and IL12B. IL-23 functions in innate and adaptive immunity. IL-23 binds to a...
Monocyte differentiation antigen CD14 (CD14) cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). CD14...
Endothelin-converting enzyme 1 (ECE-1) is an enzyme that hydrolyzes hydrolysis the 21-Trp-|-Val-22 bond in big endothelin, thus forming endothelin 1. Defects...
Gastrin corresponds to aa 76-92 of progastrin. Gastrin stimulates the stomach mucosa to produce hydrochloric acid and the pancreas to secrete digestive...
Fos-related antigen 2 (FOSL2 or Fra-2) is a transcription factor from the Fos gene family that includes Fos, FosBovine, FosL1 and FosL2. These genes encode...
TNF receptor-associated factor 3 (TRAF3) regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the...
TNF receptor-associated factor 6 (TRAF6) is a E3 ubiquitin ligase that, together with UBE2N and UBE2V1,Mouse,ediates the synthesis of...
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